Dengue is a mosquito-borne illness caused by dengue viruses 1 through 4. Dengue has resurged globally with larger outbreaks in endemic areas and new cases in nonendemic regions, facilitated by range expansion of vector mosquito populations and climate change, population growth, and urbanization.¹

Dengue is a growing health threat in the US. In 2023, the US Centers for Disease Control and Prevention (CDC) reported 1890 travel-associated cases.^2,3 As more travelers return to the US with dengue virus infection, the risk of local mosquito-borne transmission increases. Aedes aegypti and Aedes albopictus mosquitoes, which can become infected and spread dengue virus if they bite an infected person (eg, returning travelers), are present in many states. Although dengue virus transmission in US states is uncommon, locally acquired cases are reported regularly from south Florida, with 189 cases identified in 2023. Between 2010 and 2023, locally acquired cases have also been reported in Hawaiʻi (250), Texas (40), Arizona (2), and California (2).