말라리아 통제를 위한 이버멕틴 — 군집 무작위 배정 임상시험 Ivermectin to Control Malaria — A Cluster-Randomized Trial

To the Editor: Chaccour et al. (July 24 issue)¹ report that mass administration of ivermectin led to a 26% lower incidence of malaria than albendazole in the BOHEMIA (Broad One Health Endectocide-Based Malaria Intervention in Africa) trial. However, we have two reasons to question the robustness of this result. First, there was an imbalance in malaria positivity at baseline (35.6% in the ivermectin group vs. 27.5% in the albendazole group), which is a greater relative difference than that seen for the primary efficacy outcome (incidence of malaria infection, 2.20 vs. 2.66 per child-year at risk). Without adjustment for this imbalance, . . .